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Efforts to develop methods for in vivo evaluation of the native β‐cell mass
Author(s) -
Schneider S.
Publication year - 2008
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2008.00944.x
Subject(s) - in vivo , sampling (signal processing) , visualization , computer science , mass cytometry , data science , biochemical engineering , artificial intelligence , chemistry , engineering , biology , computer vision , microbiology and biotechnology , biochemistry , filter (signal processing) , gene , phenotype
Visualization and quantification of the native β‐cell mass in vivo in humans appear to be important in the study of the natural course of diabetes, and in ongoing trials aimed at preserving β‐cell mass in patients with diabetes. This cannot be done by biopsy sampling, and therefore there is a great need for development of a non‐invasive method. This article discusses the principle theoretical requirements for reaching this goal. In addition, it provides an overview of tracer probes, which have been examined as potential β‐cell mass imaging agents in the past. Finally, some future perspectives are discussed.