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Effect of raisin consumption on oxidative stress and inflammation in obesity
Author(s) -
Rankin J. W.,
Andreae M. C.,
Oliver Chen C.Y.,
O’Keefe S. F.
Publication year - 2008
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2008.00867.x
Subject(s) - oxidative stress , postprandial , oxygen radical absorbance capacity , medicine , endocrinology , endothelial dysfunction , inflammation , overweight , crossover study , metabolic syndrome , placebo , obesity , insulin , alternative medicine , pathology , antioxidant capacity
Aim: Oxidative stress can initiate increased inflammation that elevates risk for cardiovascular disease. The objective of this study was to determine the effects of daily consumption of raisins on markers of oxidative stress, inflammation and endothelial activation in response to an acute high‐fat meal in overweight individuals. Methods: Seventeen overweight men and women consumed 90 g raisins or isocaloric placebo (264 kcal/day) for 14 days in a randomized, crossover design while following a low‐flavonoid diet. The oxidative [urinary 8‐iso‐prostaglandin‐F 2α (8‐epi PGF 2α ) and serum oxygen radical absorbance capacity (ORAC)], inflammatory (serum C‐reactive protein and interleukin‐6), endothelial (serum soluble intercellular adhesion molecule‐1 and soluble vascular cell adhesion molecule‐1, sVCAM‐1) and metabolic [free fatty acids (FFAs), triacylglycerol, glucose and insulin] response to four high‐fat (53%) meals was tested pre‐ and postintervention. Results: Urinary 8‐epi PGF 2α decreased (−22%) and fasting ORAC increased (+3%) after both interventions combined. Fasting protein‐free ORAC was modestly (+3.5%) higher during the raisin than the placebo intervention. Neither the meals nor the raisins consistently induced fasted markers of inflammation or endothelial dysfunction. Gender influenced postprandial metabolic responses in that males responded with higher serum FFAs, sVCAM‐1 and glucose compared with females. Conclusions: Serum antioxidant capacity was modestly increased by daily raisin consumption, but this did not alter fasted or postprandial inflammatory response in these relatively healthy but overweight individuals. Providing all food in regular pattern reduced measures of oxidative stress.