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Regulation of β‐cell mass and function by the Akt/protein kinase B signalling pathway
Author(s) -
Elghazi L.,
Rachdi L.,
Weiss A. J.,
CrasMéneur C.,
BernalMizrachi E.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2007.00783.x
Subject(s) - protein kinase b , microbiology and biotechnology , pi3k/akt/mtor pathway , signal transduction , kinase , function (biology) , chemistry , protein kinase a , biology
The insulin receptor substrate‐2/phosphoinositide 3‐kinase (PI3K) pathway plays a critical role in the regulation of β‐cell mass and function, demonstrated both in vitro and in vivo . The serine threonine kinase Akt is one of the promising downstream molecules of this pathway that has been identified as a potential target to regulate function and induce proliferation and survival of β cells. Here we summarize some of the molecular mechanisms, downstream signalling pathways and critical components involved in the regulation of β‐cell mass and function by Akt.