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Plasma adipocyte and epidermal fatty acid binding protein is reduced after weight loss in obesity
Author(s) -
Haider D. G.,
Schindler K.,
Bohdjalian A.,
Prager G.,
Luger A.,
Wolzt M.,
Ludvik B.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2007.00717.x
Subject(s) - medicine , endocrinology , fatty acid binding protein , insulin resistance , body mass index , metabolic syndrome , adipocyte , weight loss , obesity , chemistry , adipose tissue , biochemistry , gene
Aim: Plasma adipocyte fatty acid binding protein (A‐FABP) and epidermal fatty acid binding protein (E‐FABP) concentrations have been linked to obesity and the metabolic syndrome. In this study, we investigated whether plasma A‐FABP and E‐FABP concentrations are altered by weight loss in obese patients. Methods: In a prospective study, fasting plasma A‐FABP and E‐FABP concentrations were measured before and 6 months after gastric banding in 33 morbidly obese patients, with a body mass index (BMI) of 46 ± 5 kg/m 2 . Eleven healthy subjects with a BMI < 25 kg/m 2 served as controls. Results: A‐FABP and E‐FABP plasma concentrations were higher in obese subjects (36.7 ± 6.7 and 3.7 ± 0.7 ng/ml, respectively) than in controls (18.1 ± 0.6 and 2.6 ± 0.5, respectively, p < 0.01). Gastric banding reduced BMI to 40 ± 5 kg/m 2 , A‐FABP to 32.6 ± 5.4 ng/ml and E‐FABP to 1.9 ± 0.7 ng/ml (all p < 0.05) after 6 months. Insulin sensitivity as estimated by the Homeostasis Model Assessment insulin resistance index was unchanged. A‐FABP concentrations were significantly associated with BMI before and 6 months after surgery (p < 0.05, r = 0.42 and r = 0.37 respectively). Conclusions: Elevated plasma A‐FABP and E‐FABP concentrations in morbidly obese subjects are reduced after gastric banding–induced weight loss. This suggests that FABP may be associated with improvement of metabolic conditions over time.