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Low serum high‐density lipoprotein cholesterol in obese subjects with normal serum triglycerides: the role of insulin resistance and inflammatory cytokines
Author(s) -
Mooradian A. D.,
Albert S. G.,
Haas M. J.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2006.00636.x
Subject(s) - medicine , insulin resistance , endocrinology , hypertriglyceridemia , obesity , body mass index , triglyceride , insulin , high density lipoprotein , cholesterol
Background: The cause of obesity‐related low HDLc in the absence of hypertriglyceridemia is not known. Subjects & methods: A total of 32 subjects with a body mass index (BMI)(kg/m 2 ) greater than 30 and normal serum triglycerides (<150 mg/dl) were identified. Results: People with low HDLc (n = 16) compared to those with normal HDLc (n = 16) had higher BMI (37.53 ± 4.54 vs. 33.99 ± 3.65 kg/m 2 , p < 0.021), higher body fat weight (42.59 ± 9.51 vs. 34.76 ± 8.7 kg, p < 0.023), and higher insulin resistance index (3.75 ± 2.51 vs. 1.95 ± 1.10, p < 0.013). Seven subjects with low HDLc and none of those with normal HDLc, had elevated serum tumor necrosis factor alpha and/or interleukin‐6 (p < 0.010). Conclusions: Low HDLc levels can occur in obesity independently of elevated serum triglycerides and may be secondary to elevated serum levels of inflammatory cytokines.