Premium
Raised alanine transaminase and decreased adiponectin are features of the metabolic syndrome in patients with type 2 diabetes
Author(s) -
Hickman Ingrid J.,
Whitehead Jonathan P.,
Prins Johannes B.,
Macdonald Graeme A.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2006.00604.x
Subject(s) - adiponectin , medicine , alanine transaminase , type 2 diabetes , endocrinology , metabolic syndrome , aspartate transaminase , radioimmunoassay , diabetes mellitus , transaminase , alanine aminotransferase , gastroenterology , insulin resistance , chemistry , enzyme , alkaline phosphatase , biochemistry
Aim: The aim of the study was to investigate the relationship between the metabolic syndrome (MS), adiponectin and abnormal liver enzymes in patients with type 2 diabetes. Methods: Fasting serum was collected from 189 patients with type 2 diabetes, adiponectin was measure using radioimmunoassay and features of the MS were assessed. Results: Mean ALT was significantly higher in patients with the MS and higher ALT was associated with lower adiponectin levels. As the number of features of MS increased, ALT increased and adiponectin decreased independent of glycaemic control. Conclusion: Hypoadiponectinemia and the MS may be linked with liver injury in patients with type 2 diabetes.