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Ectopic fat accumulation and metabolic syndrome
Author(s) -
Rasouli Neda,
Molavi Behzad,
Elbein Steven C.,
Kern Philip A.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2006.00590.x
Subject(s) - metabolic syndrome , insulin resistance , obesity , medicine , abdominal obesity , diabetes mellitus , pathogenesis , bioinformatics , pathophysiology , intensive care medicine , endocrinology , biology
The recent escalation of obesity from an individual health problem to a major public health issue reaching epidemic proportions has drawn attention to a constellation of abnormalities (abdominal obesity, hypertension and dyslipidaemia) collectively referred to as metabolic syndrome. As an indicator of insulin resistance and a harbinger of diabetes, this syndrome has been associated with major cardiovascular mortality and morbidity. Yet, the exact pathophysiological events leading to the development of metabolic syndrome remain unknown. We review some of the current literature on the pathogenesis of metabolic syndrome with an emphasis on the role of ectopic lipid accumulation.