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Pharmacological inhibition of TRα1 receptor potentiates the thyroxine effect on body weight reduction in rats: potential therapeutic implications in controlling body weight
Author(s) -
Pantos C.,
Mourouzis I.,
Paizis I.,
Malliopoulou V.,
Xinaris Ch.,
Moraitis P.,
Cokkinos A. D.,
Cokkinos D. V.
Publication year - 2007
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2006.00587.x
Subject(s) - thyroid , endocrinology , medicine , hormone , amiodarone , thyroid hormone receptor , body weight , receptor , weight loss , chemistry , thyroid hormones , obesity , atrial fibrillation
It has been previously reported that thyroid hormone receptor α1 (TRα1) is involved in the regulation of food intake and heart rhythm. Herein, we show that pharmacological inhibition of TRα1 by dronedarone, an amiodarone like compound (shown to antagonize thyroid hormone binding to TRα1), prevented the thyroid hormone induced increase in food intake and heart rate acceleration in rats. This resulted in a marked reduction in body weight. It is likely that thyroid analogs may prove potential therapeutic agents for controlling body weight.