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Effects of oestrogen receptor‐active compounds on lipid metabolism
Author(s) -
Lakoski Susan G.,
Herrington David M.
Publication year - 2005
Publication title -
diabetes, obesity and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.445
H-Index - 128
eISSN - 1463-1326
pISSN - 1462-8902
DOI - 10.1111/j.1463-1326.2004.00412.x
Subject(s) - tibolone , raloxifene , selective estrogen receptor modulator , tamoxifen , osteoporosis , lipid metabolism , breast cancer , medicine , oestrogen receptor , estrogen receptor , mechanism (biology) , mechanism of action , endocrinology , pharmacology , estrogen , bone remodeling , chemistry , cancer , biochemistry , philosophy , epistemology , in vitro
Selective estrogen receptor modulators (SERMs) have been used successfully in the treatment of breast cancer and osteoporosis while Tibolone has been used extensively in Europe for the treatment of menopausal symptoms. Limited data is available on the effect of these agents on the cardiovascular system. Traditional and novel lipid markers are valuable in determining patients at increased cardiovascular risk. The purpose of this article is to discuss the mechanism of action of Tamoxifen, Raloxifene and Tibolone and their effects on lipid metabolism.