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Colorectal cancer complicating inflammatory bowel disease: a comparative study of Crohn’s disease vs ulcerative colitis in 34 patients
Author(s) -
Ouaïssi M.,
Maggiori L.,
Alves A.,
Giger U.,
Sielezneff I.,
Valleur P.,
Sastre B.,
Panis Y.
Publication year - 2011
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/j.1463-1318.2010.02241.x
Subject(s) - medicine , ulcerative colitis , gastroenterology , inflammatory bowel disease , colorectal cancer , disease , cancer , crohn's disease , colitis
Aim Colorectal cancer (CRC) complicating inflammatory bowel disease (IBD) accounts for 10–15% of all IBD deaths. Survival of patients with IBD‐related CRC was reviewed to analyse differences between ulcerative colitis (UC) and Crohn’s disease (CD). Method We analysed (24 men and 10 women) patients with CD ( n = 14) or UC ( n = 20) with CRC, who presented between 1990 and 2007, and were followed to October, 2009. Results The mean age of patients was 56 ± 12 years for patients with UC and 49 ± 17 years for patients with CD, and the mean duration of symptoms was 22 ± 11 and 16 ± 8 years, respectively. The median duration of follow up after the diagnosis of CRC was 49 (1–157) months. Recurrence occurred in five patients with UC and in nine with CD ( P = 0.02). The overall and disease free five year survivals were significantly higher in patients with UC than CD [70% vs 43% ( P = 0.01) and 63% vs 31% ( P = 0.01), respectively]. Conclusion The results showed a poorer prognosis of CRC in patients with CD than with UC.