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Comparison of the prognostic value of tumour‐ and patient‐related factors in patients undergoing potentially curative surgery for colon cancer
Author(s) -
Roxburgh C. S. D.,
Wallace A. M.,
Guthrie G. K.,
Horgan P. G.,
McMillan D. C.
Publication year - 2010
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/j.1463-1318.2009.01961.x
Subject(s) - medicine , colorectal cancer , stage (stratigraphy) , multivariate analysis , cancer , gastroenterology , surgery , colonic cancer , alkaline phosphatase , paleontology , biology , biochemistry , chemistry , enzyme
Aim To comprehensively compare the prognostic value of tumour‐ and patient‐related factors in patients undergoing curative surgery for colon cancer. Method From a database of 287 patients who underwent elective resection between 1997 and 2005, tumour factors including stage and host factors including systemic inflammatory response [modified Glasgow Prognostic Score (mGPS)] were identified. Results Median follow‐up was 65 months. Over this period, 125 patients died, 80 from cancer. On multivariate analysis of all significant patient and tumour related factors, Dukes stage ( P < 0.01), vascular invasion ( P < 0.01) and the mGPS ( P < 0.01) were independently associated with cancer‐survival. Of the patient‐related factors, age ( P < 0.01), haemoglobin ( P < 0.01), white‐cell ( P < 0.01), neutrophil ( P < 0.01) and platelet ( P < 0.01) counts, and alkaline phosphatase ( P < 0.01) were most significantly associated with the mGPS. Conclusion In addition to tumour‐related factors such as Dukes stage and vascular invasion, the preoperative mGPS should be included to guide prognosis in patients undergoing curative resection for colon cancer.