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Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial
Author(s) -
Mistrangelo M.,
Cornaglia S.,
Pizzio M.,
Rimonda R.,
Gavello G.,
Dal Conte I.,
Mussa A.
Publication year - 2010
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/j.1463-1318.2009.01960.x
Subject(s) - medicine , surgery , immunosuppression , randomized controlled trial , incidence (geometry) , immunostimulant , condyloma acuminatum , randomization , informed consent , immune system , human papillomavirus , immunology , pathology , physics , alternative medicine , optics
Aim Human papillomavirus is the most common cause of sexually transmitted disease. It is associated with immunosuppression and shows a marked tendency to recur. We investigated a natural immunostimulant aimed to reduce recurrence. Method A randomized controlled study was carried out including 261 patients allocated to surgical excision alone (control group; n = 122) and surgical excision plus postoperative immunostimulation for 30 days with a natural product (STET; study group; n = 139). Patients with HIV positivity were excluded. All patients gave fully informed consent. Results The patients were followed for 6 months after surgery. Recurrence occurred in 7.2% (10/139) in the study group and in 27.1% (33/122) in the control group ( P < 0.0001). There were no significant differences in the sex, sexual orientation, number of lesions, time to diagnosis and treatment or localization of lesions in the two groups. Conclusions Immunostimulation using a natural product significantly reduced the incidence of recurrence of anal condylomata in patients undergoing surgical excision.