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p73 expression and its clinical significance in colorectal cancer
Author(s) -
Su X.L.,
Ouyang X.H.,
Yan M.R.,
Liu G.R.
Publication year - 2009
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/j.1463-1318.2008.01736.x
Subject(s) - colorectal cancer , medicine , clinical significance , immunohistochemistry , messenger rna , in situ hybridization , cancer , metastasis , oncology , cancer research , pathology , gene , biology , biochemistry
Objective To explore p73 mRNA and p73 protein expression and their clinical significance in colorectal cancer. Method p73 mRNA and p73 protein expression were detected using hybridization in situ and immunohistochemical method in cancerous tissue from 60 patients of colorectal cancer and in paracancerous tissue from 23 patients among the corresponding 60 patients of colorectal cancer. Quantitative analysis was performed using Smartscape image analysis system. Results Compared with paracancerous tissue, p73 mRNA and p73 protein expression in cancerous tissue was increased with a statistically significant difference ( P < 0.01) and was associated with differentiation level and lymphatic metastasis. Conclusion High expression of p73 mRNA and p73 protein in colorectal cancer may be involved in the progression of colorectal cancer and p73 mRNA and p73 protein may serve as a potential index to predict differentiation level and prognosis of colorectal cancer.