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Epidermal growth factor receptor in colorectal carcinoma: correlation with clinico‐pathological prognostic factors
Author(s) -
Abd El All H. S.,
Mishriky A. M.,
Mohamed F. A.
Publication year - 2008
Publication title -
colorectal disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.029
H-Index - 89
eISSN - 1463-1318
pISSN - 1462-8910
DOI - 10.1111/j.1463-1318.2007.01306.x
Subject(s) - medicine , perineural invasion , colorectal cancer , pathological , oncology , epidermal growth factor receptor , correlation , stage (stratigraphy) , gastroenterology , cancer , paleontology , geometry , mathematics , biology
Objective This study was undertaken to determine the relationship between epidermal growth factor receptor (EGFR) status in primary colorectal cancer (CRC) to different clinico‐pathological prognostic factors. Method Seventy‐nine primary CRC were studied using four scoring systems: 1‐ EGFR pharmDx score, 2‐ score modified from the Hercept test [ J Histo cytochem , 52 (2004) 893], 3‐ two additive scores with different cutoff points [ Mod Pathol , 11 (1998) 155], 4‐ two multiplicative scores with different cutoff points [ Ann Oncol , 16 (2005) 102]. Results More than 10% membranous EGFR reactivity was identified in 46.8% (37/79) of the tumours. The intensity was classified as mild, moderate and strong representing 8.9%, 20.3% and 17.7% respectively. Strong correlation was found between the EGFR pharmDx and the proposed scores, at different cutoff points ( P < 0.01). A strong correlation was found between EGFR expression, advanced clinical stage ( P < 0.01), nodal involvement ( P < 0.01) and lympho‐vascular invasion (LV) ( P < 0.05) in category I factors, poorly differentiated tumours in IIA ( P < 0.05), infiltrative border configuration in IIB ( P < 0.01), perineural invasion (PN) in III ( P < 0.01), and larger tumours in IV ( P < 0.01). Heterogenous staining was present in 46.3% of tumours and was associated with an increased score, LV and PN invasion and advanced clinical stage ( P < 0.05). Conclusion Using a cut‐off point of 10%, similar results with different scoring systems were obtained, representing standardization for EGFR interpretation. EGFR expression is correlated with conventional clinico‐pathological prognostic factors.