Open AccessBacterial subversion of host actin dynamics at the plasma membrane
Author(s) -
Carabeo Rey
Publication year - 2011
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/j.1462-5822.2011.01651.x
Subject(s) - biology , actin , microbiology and biotechnology , internalization , actin cytoskeleton , cytoskeleton , subversion , actin remodeling , cell , genetics , politics , political science , law
Summary Invasion of non‐phagocytic cells by a number of bacterial pathogens involves the subversion of the actin cytoskeletal remodelling machinery to produce actin‐rich cell surface projections designed to engulf the bacteria. The signalling that occurs to induce these actin‐rich structures has considerable overlap among a diverse group of bacteria. The molecular organization within these structures act in concert to internalize the invading pathogen. This dynamic process could be subdivided into three acts – actin recruitment, engulfment, and finally, actin disassembly/internalization. This review will present the current state of knowledge of the molecular processes involved in each stage of bacterial invasion, and provide a perspective that highlights the temporal and spatial control of actin remodelling that occurs during bacterial invasion.