Open AccessUbiquitylation and autophagy in the control of bacterial infections and related inflammatory responses
Author(s) -
Ligeon LaureAnne,
TemimeSmaali Nassima,
Lafont Frank
Publication year - 2011
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/j.1462-5822.2011.01628.x
Subject(s) - autophagy , biology , effector , ubiquitin , microbiology and biotechnology , signalling pathways , signalling , host (biology) , proteasome , computational biology , signal transduction , genetics , apoptosis , gene
Summary The ubiquitin proteasome system and autophagy constitute key signalling pathways in the host response to infection. The identification of adaptors linking the two pathways has prompted a re‐examination of the latter's involvement in inflammatory reactions and the clearance of bacteria. The ubiquitin–autophagy pathway is a preferred target for effectors from pathogens that seek to exploit and evade the host defence mechanisms. A number of new players and signalling nodes have recently been identified. Here, we discuss these new insights into the host's control of bacterial infection.