Open AccessThe bacterial second messenger c‐di‐GMP: mechanisms of signalling
Author(s) -
Mills Erez,
Pultz Ingrid S.,
Kulasekara Hemantha D.,
Miller Samuel I.
Publication year - 2011
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/j.1462-5822.2011.01619.x
Subject(s) - signalling , second messenger system , biology , intracellular , cyclic gmp , signalling pathways , microbiology and biotechnology , signal transduction , enzyme , computational biology , biochemistry
Summary Cyclic‐di‐GMP (c‐di‐GMP) regulates many important bacterial processes. Freely diffusible intracellular c‐di‐GMP is determined by the action of metabolizing enzymes that allow integration of numerous input signals. c‐di‐GMP specifically regulates multiple cellular processes by binding to diverse target molecules. This review highlights important questions in research into the mechanisms of c‐di‐GMP signalling and its role in bacterial physiology.