Open AccessImmunologic considerations for generating memory CD8 T cells through vaccination
Author(s) -
Butler Noah S.,
Nolz Jeffrey C.,
Harty John T.
Publication year - 2011
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/j.1462-5822.2011.01594.x
Subject(s) - vaccination , biology , cd8 , cytotoxic t cell , immunological memory , immunology , immunity , antigen , immune system , memory cell , virology , genetics , physics , transistor , quantum mechanics , voltage , in vitro
Summary Following infection or vaccination, naïve CD8 T cells that receive the appropriate integration of antigenic, co‐stimulatory and inflammatory signals undergo a programmed series of biological changes that ultimately results in the generation of memory cells. Memory CD8 T cells, in contrast to naïve cells, more effectively limit or prevent pathogen re‐infection because of both qualitative and quantitative changes that occur following their induction. Unlike vaccination strategies aimed at generating antibody production, the ability to generate protective memory CD8 T cells has proven more complicated and problematic. However, recent experimental results have revealed important principles regarding the molecular and genetic basis for memory CD8 T cell formation, as well as identified ways to manipulate their development through vaccination, resulting in potential new avenues to enhance protective immunity.