Open AccessMolecular motors hijacking by intracellular pathogens
Author(s) -
Henry Thomas,
Gorvel JeanPierre,
Méresse Stéphane
Publication year - 2006
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/j.1462-5822.2005.00649.x
Subject(s) - dynein , biology , molecular motor , microtubule , kinesin , microbiology and biotechnology , intracellular , motor protein , actin , cytoskeleton , mitosis , compartment (ship) , organelle , cell , genetics , oceanography , geology
Summary Cargoes are transported intracellularly along cytoskeletal tracks composed of actin or tubulin. Their movement involves the action of molecular motor proteins that generate directed movement along microtubules or actin filaments. The three classes of molecular motors – kinesins, dyneins and myosins – are involved in a multiplicity of biological movements such as mitosis, positioning of organelles, intracellular transports and also vesicular sorting through membrane tubulation and fission and delivery to their target compartment. Intracellular pathogens use this molecular machinery to reach their site of replication, to leave their host or to control the dynamics of membrane exchanges with their replication compartment.