Premium
Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa
Author(s) -
KlepacCeraj Vanja,
Lemon Katherine P.,
Martin Thomas R.,
Allgaier Martin,
Kembel Steven W.,
Knapp Alixandra A.,
Lory Stephen,
Brodie Eoin L.,
Lynch Susan V.,
Bohannan Brendan J. M.,
Green Jessica L.,
Maurer Brian A.,
Kolter Roberto
Publication year - 2010
Publication title -
environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.954
H-Index - 188
eISSN - 1462-2920
pISSN - 1462-2912
DOI - 10.1111/j.1462-2920.2010.02173.x
Subject(s) - pseudomonas aeruginosa , cystic fibrosis , biology , antibiotics , genotype , respiratory tract , microbiology and biotechnology , respiratory tract infections , lung , respiratory system , disease , respiratory disease , bacteria , immunology , medicine , gene , genetics , anatomy
Summary Polymicrobial bronchopulmonary infections in cystic fibrosis (CF) cause progressive lung damage and death. Although the arrival of Pseudomonas aeruginosa often heralds a more rapid rate of pulmonary decline, there is significant inter‐individual variation in the rate of decline, the causes of which remain poorly understood. By coupling culture‐independent methods with ecological analyses, we discovered correlations between bacterial community profiles and clinical disease markers in respiratory tracts of 45 children with CF. Bacterial community complexity was inversely correlated with patient age, presence of P. aeruginosa and antibiotic exposure, and was related to CF genotype. Strikingly, bacterial communities lacking P. aeruginosa were much more similar to each other than were those containing P. aeruginosa , regardless of antibiotic exposure. This suggests that community composition might be a better predictor of disease progression than the presence of P. aeruginosa alone and deserves further study.