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Local anesthetics and their adjuncts
Author(s) -
Mazoit JeanXavier
Publication year - 2012
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2011.03692.x
Subject(s) - medicine , membrane , amide , amino acid , cytosol , sodium channel , phospholipid , pharmacology , sodium , biochemistry , biophysics , organic chemistry , chemistry , biology , enzyme
Summary Local anesthetics (LA) block propagation of impulses along nerve fibers by inactivation of voltage‐gated sodium channels, which initiate action potentials (1). They act on the cytosolic side of phospholipid membranes. Two main chemical compounds are used, amino esters and amino amides. Amino esters are degraded by pseudocholinesterases in plasma. Amino amides are metabolized exclusively by the liver. Only amide LAs will be considered in this article.