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Intranasal flumazenil and naloxone to reverse over‐sedation in a child undergoing dental restorations
Author(s) -
HEARD CHRISTOPHER,
CREIGHTON PAUL,
LERMAN JERROLD
Publication year - 2009
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2009.03069_1.x
Subject(s) - medicine , flumazenil , laryngospasm , midazolam , sedation , sufentanil , anesthesia , (+) naloxone , positive pressure ventilation , benzodiazepine , antagonist , airway , respiratory failure , receptor
Summary We describe a 3‐year‐old child who became over‐sedated after receiving intranasal (IN) midazolam (0.53 mg·kg −1 ) and IN sufentanil (1 mcg·kg −1 ) for dental restorations in the dental office. Desaturation was attributed to laryngospasm, which was managed with positive pressure ventilation and oxygen. The sedation was reversed with a combination of IN flumazenil and naloxone.