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Continuous incisional infusion of local anesthetic in pediatric patients following open heart surgery
Author(s) -
TIROTTA CHRISTOPHER F.,
MUNRO HAMISH M.,
SALVAGGIO JANE,
MADRIL DANIELLE,
FELIX DONALD E.,
RUSINOWSKI LYNDA,
TYLER CRISTI,
DECAMPLI WILLIAM,
HANNAN ROBERT L.,
BURKE REDMOND P.
Publication year - 2009
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2009.03009.x
Subject(s) - medicine , anesthesia , levobupivacaine , midazolam , ketorolac , sedation , local anesthetic , surgery , placebo , morphine , bupivacaine , saline , analgesic , catheter , alternative medicine , pathology
Summary Aim: To determine the efficacy and safety of a continuous subcutaneous local anesthetic (LA) infusion in pediatric patients following open heart surgery. Background: The use of a continuous LA infusion has been shown to be beneficial following adult cardiac surgery. To date there are no studies in the pediatric population. Methods/Materials: Using a prospective, randomized, and double blind design, we compared LA, either 0.25% levobupivacaine or bupivacaine (Treatment Group) to saline (Placebo Group) delivered subcutaneously via a continuous infusion for 72 h after open heart surgery in 72 patients. Requirements for postoperative analgesics and pain scores were recorded for 72 h and plasma levels of local anesthetic were measured. Secondary outcomes measures included time to first oral intake, time to first bowel movement, time to urinary catheter removal, length of stay, requirements for antiemetics and additional sedation. Results: Total morphine requirements over the first 24 h were less in the Treatment Group than the Placebo Group (0.05 mg·kg −1 vs 0.2 mg·kg −1 , P = 0.007); this was true for all patient groups except those patients weighing less than 6.3 kg. The number of patients requiring no morphine was greater in the Treatment Group (7/35 vs 1/37, P = 0.02). The Treatment Group also received less midazolam, lorazepam, and ketorolac than the Placebo Group over 72 h due to the reduced clinical need for these agents in patients weighing less than 31 kg. There were no differences in secondary outcomes. Conclusions: A continuous incisional infusion of LA reduced postoperative analgesic requirement and sedative use in pediatric patients undergoing a median sternotomy incision. Dosed at a maximum rate of 0.4 mg·kg −1 ·h −1 , a continuous incisional infusion of LA is effective and safe for up to 72 h, with plasma levels of local anesthetic well below the toxic threshold.