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Bradycardia with sevoflurane in siblings with branchio‐oto‐renal syndrome
Author(s) -
TAYLOR MATTHEW H.G.,
WILTON NIALL C.T.
Publication year - 2007
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2006.02024.x
Subject(s) - medicine , bradycardia , sevoflurane , anesthesia , atropine , epinephrine , heart rate , blood pressure
Summary Branchio‐oto‐renal syndrome (BOR, Melnick–Fraser syndrome, MIM#113650) refers to a rare autosomal dominant disorder characterized by branchial cysts or fistulas, hearing loss, external ear malformation, preauricular pits and renal abnormalities. The authors present three episodes of significant bradycardia in two siblings diagnosed with BOR syndrome during the sevoflurane general anesthesia. There is no published experience of anesthesia with this syndrome. Bradycardia occurred variously at induction, maintenance and immediately prior to emergence and required surgical stimulation, atropine, or epinephrine to treat. We seek to raise awareness of the potential for bradycardia during the procedures in patients with this syndrome requiring volatile anesthesia, especially sevoflurane.