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Resistance to cisatracurium in a patient with MELAS syndrome
Author(s) -
AOUAD MARIE T.,
GERGES FREDERIC J.,
BARAKA ANIS S.
Publication year - 2005
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2005.01583.x
Subject(s) - medicine , melas syndrome , intensive care medicine , mitochondrial myopathy , genetics , mitochondrial dna , biology , gene
Summary There are conflicting reports on the response of mitochondrial myopathy patients to the neuromuscular blocking drugs, showing either normal response or marked sensitivity. We present a patient with MELAS syndrome who underwent Nissen fundoplication and gastrojejunostomy. Marked resistance to the nondepolarizing muscle relaxant, cisatracurium was observed. The anesthesia management, as well as the various causes of resistance to cisatracurium in this patient are discussed.