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A prospective study comparing the analgesic efficacy of levobupivacaine, ropivacaine and bupivacaine in pediatric patients undergoing caudal blockade
Author(s) -
Breschan Christian,
Jost Robert,
Krumpholz Ruth,
Schaumberger Florian,
Stettner Haro,
Marhofer Peter,
Likar Rudolf
Publication year - 2005
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.2004.01443.x
Subject(s) - levobupivacaine , medicine , ropivacaine , analgesic , bupivacaine , anesthesia , motor block , surgery , blockade , receptor
Summary Background: The aim of our study was to compare postoperative analgesic efficacy, analgesic duration and motor blockade of levobupivacaine, ropivacaine and bupivacaine administered caudally in equal concentrations to children undergoing elective minor surgery. Methods: In the study, 182 children, aged 1–7 years, undergoing either inguinal hernia repair or orchidopexy, were randomly allocated to one of the three groups. They received via a caudal extradural either 1 ml·kg −1 levobupivacaine 0.2% (Group L) or 1 ml·kg −1 ropivacaine 0.2% (Group R) or 1 ml·kg −1 bupivacaine 0.2% (Group B). Results: No statistically significant difference was noted in age, weight, duration of the operation or level of the caudal block between the groups. The onset of analgesia was significantly later after levobupivacaine. Postoperative pain scoring evaluated with Children's and Infant's Postoperative Pain Scale observational scale showed no statistical difference between groups. Median postoperative analgesia was 5.75 h (SEMed: ± 0.65) in Group L, 5.7 h (SEMed: ± 0.8) in Group R and 5.35 h (SEMed: ± 1.3) in Group B the difference being statistically nonsignificant. Conclusions: The degree of motor block was significantly less after ropivacaine and levobupivacaine during the first 2 h postoperatively.