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New regimen for interpleural block in children
Author(s) -
GIAUFRÉ ELISABETH,
BRUGUEROLLE BERNARD,
RASTELLO CÉLINE,
COQUET MICHEL,
LOREC ANNE MARIE
Publication year - 1995
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.1995.tb00259.x
Subject(s) - medicine , regimen , bupivacaine , anesthesia , premedication , surgery , orosomucoid , plasma concentration , pharmacokinetics , pharmacology , glycoprotein , microbiology and biotechnology , biology
Summary A new regimen for postoperative analgesia after thoracic surgery is proposed. Eight children received an interpleural infusion using bupivacaine 0.1% in a regimen from 0.5 ml·kg −1 ·h −1 up to 1 ml·kg −1 ·h −1 , for 48 h according to the pain scores. The plasma levels after 24 h and 48 h were measured as well as the pleural level and in two patients the free fraction of plasma bupivacaine and the plasma PPX (a metabolite of bupivacaine) and one patient the orosomucoid (main plasma protein involved in bupivacaine protein binding) were also measured pre and postoperatively. The results shows the safety of such a regimen, for two days of postoperative analgesia.