Premium
Rectal midazolam as premedicant in children: a dose response study
Author(s) -
ANDERSEN GERTRUD,
PEDERSEN NIELS ANKER,
JOHANSSON GUN,
STJERNHOLM PIA,
REINSTRUP PETER
Publication year - 1994
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.1994.tb00410.x
Subject(s) - midazolam , medicine , premedication , sedation , anesthesia , dose , sedative , atropine , pharmacology
Rectally administered midazolam has proved to be a reliable and acceptable way of premedicating children. In order to determine the optimal dose 80 children were randomized in a double‐blind manner to receive one of four different dosages of midazolam (0.2–0.3–0.4–0.5 mg·kg −1 ) in combination with atropine 0.02 mg·kg −1 rectally. Observations before and after premedication showed no clinically relevant differences in ventilatory and cardiovascular parameters. Neither did the groups differ as regards acceptance of the mask or awakening from anaesthesia. Regardless of group the level of sedation was increased, but only children receiving 0.4 or 0.5 mg·kg −1 of midazolam showed an increase in the level of anxiolysis. For this reason a low dose of midazolam (0.2 mg·kg −1 ) can be used, except in cases where pronounced anxiolysis is required.