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Atracurium in the neonate. Dose‐response with halothane
Author(s) -
FFARCS A.J. CHARLTON,
FFARCS N.J.N. HARPER,
WILSON A.C.,
HUNT L.P.
Publication year - 1994
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.1994.tb00116.x
Subject(s) - halothane , medicine , nitrous oxide , anesthesia , narcotic , stimulation
Summary Atracurium in doses of 40, 65, 85 or 100 μg·kg −1 was given to four groups of five neonates anaesthetized with nitrous oxide and halothane. The dose‐response relationship was determined by measurement of the EMG response to train‐of‐four stimulation. The doses calculated to produce 50 and 95% depression of the first twitch response were 56.3 and 101.3 μg·kg −1 respectively. These values are lower than those reported during nitrous oxide/oxygen/narcotic anaesthesia in neonates and older children breathing halothane. The change in train‐of‐four ratio during onset appeared similar to that observed in adults.