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Comparison of triazolam v. diazepam as an oral preanaesthetic medication for outpatient paediatric surgery
Author(s) -
BRAHEN N.H.,
EDELL L.S.,
NICOLSON S.C.,
BAKER J.D.,
COHEN D.E.,
SCHREINER M.S.
Publication year - 1992
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.1992.tb00203.x
Subject(s) - triazolam , pethidine , medicine , premedication , anesthesia , diazepam , sedation , midazolam , amnesia , outpatient surgery , benzodiazepine , surgery , ambulatory , receptor , analgesic , psychiatry
Summary Diazepam, in combination with pethidine and atropine, has proved to be an effective oral pre‐anaesthetic medication for paediatric outpatient surgery. Triazolam is a benzodiazepine with a short half‐life and rapid oral absorption, and causes amnesia and sedation. The results of a prospective, randomized, double‐blind study substituting triazolam for diazepam in this regimen are described. One hundred and nineteen healthy paediatric outpatients older than 1 year of age were randomized to receive either our routine oral outpatient premedication (pethidine 1.5 mg·kg ‐1 , diazepam 0.15 mg·kg ‐1 and atropine 0.02 mg·kg ‐1 ), an oral premedicant where triazolam (0.005 mg·kg ‐1 ) was substituted for diazepam or an oral premedicant containing pethidine and atropine only. Children given triazolam had a more rapid onset of pre‐anaesthetic medication effect (change in state of consciousness) compared with patients in the other two groups ( P < 0.01). Patients receiving traizolam showed more evidence of sedation within 45 min of receiving the oral premedication ( P < 0.003). There were no other differences between the three groups.