Premium
Histamine release from the administration of suxamethonium and atracurium in adolescents
Author(s) -
GOUDSOUZIAN N.G.,
GELB C.
Publication year - 1991
Publication title -
pediatric anesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.704
H-Index - 82
eISSN - 1460-9592
pISSN - 1155-5645
DOI - 10.1111/j.1460-9592.1991.tb00008.x
Subject(s) - histamine , medicine , anesthesia , plasma levels , plasma concentration , pharmacology
Cutaneous reactions and plasma histamine levels were evaluated in 30 adolescents subsequent to the administration of suxamethonium 1.5 mg kg −1 or atracurium 0.6 mg kg −1 . Plasma histamine levels were measured by the radio‐enzymatic assay using histamine N ‐methyl transferase. In the atracurium group, the change in plasma histamine level was significant at the 2 min mark, but was not significant in the suxamethonium group. About 60% of the patients in each group developed a cutaneous reaction. Erythematous cutaneous reactions following atracurium were frequently associated with a mild increase in plasma histamine levels, whereas the rashes induced by suxamethonium in adolescents were not associated with changes in plasma histamine.