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Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette
Author(s) -
Chapman Kevin E.,
Raol Yogendra H.,
BrooksKayal Amy
Publication year - 2012
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2012.08140.x
Subject(s) - bench to bedside , medicine , european union , intensive care medicine , engineering ethics , psychotherapist , psychology , medical physics , business , engineering , economic policy
Neonatal seizures have unique properties that have proved challenging for both clinicians and basic science researchers. Clinical therapies aimed at neonatal seizures have proven only partially effective and new therapies are slow to develop. This article will discuss neonatal seizures within the framework of the barriers that exist to the development of new therapies, and the challenges inherent in bringing new therapies from the bench to the bedside. With the European Union and USA creating national collaborative project infrastructure, improved collaborative resources should advance clinical research on urgently needed new therapies for this disorder.