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An integrated approach to design novel therapeutic interventions for demyelinating disorders
Author(s) -
Vidaurre Oscar G.,
Liu Jia,
Haines Jeffery,
Sandoval Juan,
Nowakowski Richard,
Casaccia Patrizia
Publication year - 2012
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2012.08118.x
Subject(s) - context (archaeology) , multiple sclerosis , disease , demyelinating disease , intervention (counseling) , neuroscience , medicine , demyelinating disorder , pathological , epigenome , genetic predisposition , psychology , biology , immunology , pathology , psychiatry , genetics , paleontology , gene expression , dna methylation , gene
Therapeutic strategies are often based on two general principles: interference with the pathogenic process and repair of the damaged tissues. Recent studies, however, have suggested that several pathological conditions may result from the interplay between genetic susceptibility traits and environmental influences that, by modulating the epigenome, also affect disease onset and progression. Based on lessons from neural development, it is conceivable that new lines of preventive and possibly therapeutic intervention might be developed to modulate disease onset or decrease the severity of the symptoms. This review will discuss these concepts within the context of multiple sclerosis, the most common demyelinating disease of the central nervous system, and the leading cause of progressive neurological disability in young adults.