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Transcranial direct current stimulation preconditioning modulates the effect of high‐frequency repetitive transcranial magnetic stimulation in the human motor cortex
Author(s) -
Cosentino Giuseppe,
Fierro Brigida,
Paladino Piera,
Talamanca Simona,
Vigneri Simone,
Palermo Antonio,
Giglia Giuseppe,
Brighina Filippo
Publication year - 2012
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2011.07939.x
Subject(s) - transcranial magnetic stimulation , transcranial direct current stimulation , neuroscience , motor cortex , primary motor cortex , neuroplasticity , psychology , stimulus (psychology) , stimulation , facilitation , silent period , brain stimulation , inhibitory postsynaptic potential , physical medicine and rehabilitation , medicine , psychotherapist
Experimental studies emphasize the importance of homeostatic plasticity as a mean of stabilizing the properties of neural circuits. In the present work we combined two techniques able to produce short‐term (5‐Hz repetitive transcranial magnetic stimulation, rTMS) and long‐term (transcranial direct current stimulation, tDCS) effects on corticospinal excitability to evaluate whether and how the effects of 5‐Hz rTMS can be tuned by tDCS preconditioning. Twelve healthy subjects participated in the study. Brief trains of 5‐Hz rTMS were applied to the primary motor cortex at an intensity of 120% of the resting motor threshold, with recording of the electromyograph traces evoked by each stimulus of the train from the contralateral abductor pollicis brevis muscle. This interventional protocol was preconditioned by 15 min of anodal or cathodal tDCS delivered at 1.5 mA intensity. Our results showed that motor‐evoked potentials (MEPs) increased significantly in size during trains of 5‐Hz rTMS in the absence of tDCS preconditioning. After facilitatory preconditioning with anodal tDCS, 5‐Hz rTMS failed to produce progressive MEP facilitation. Conversely, when 5‐Hz rTMS was preceded by inhibitory cathodal tDCS, MEP facilitation was not abolished. These findings may give insight into the mechanisms of homeostatic plasticity in the human cerebral cortex, suggesting also more suitable applications of tDCS in a clinical setting.