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From filopodia to synapses: the role of actin‐capping and anti‐capping proteins
Author(s) -
Menna Elisabetta,
Fossati Giuliana,
Scita Giorgio,
Matteoli Michela
Publication year - 2011
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2011.07897.x
Subject(s) - filopodia , synaptogenesis , long term potentiation , actin , microbiology and biotechnology , synaptic plasticity , synapse , dendritic filopodia , neuroscience , actin remodeling , dendritic spine , biology , chemistry , actin cytoskeleton , cytoskeleton , receptor , biochemistry , cell , hippocampal formation
Actin‐capping and anti‐capping proteins are crucial regulators of actin dynamics. Recent studies have indicated that these proteins may be heavily involved in all stages of synaptogenesis, from the emergence of filopodia, through neuritogenesis and synaptic contact stabilization, to the structural changes occurring at the synapse during potentiation phenomena. In this review, we focus on recent evidence pointing to an active role of actin‐capping and anti‐capping proteins in orchestrating the processes controlling neuronal connectivity and plasticity.