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Epigenetic regulation of neurogenesis in the adult mammalian brain
Author(s) -
Sun Jiaqi,
Sun Jiawei,
Ming Guoli,
Song Hongjun
Publication year - 2011
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2011.07607.x
Subject(s) - neurogenesis , epigenetics , epigenetic regulation of neurogenesis , biology , dna methylation , neuroscience , histone , regulation of gene expression , gene expression , gene , genetics , chromatin remodeling
Epigenetic regulation represents a fundamental mechanism to maintain cell‐type‐specific gene expression during development and serves as an essential mediator to interface the extrinsic environment and the intrinsic genetic programme. Adult neurogenesis occurs in discrete regions of the adult mammalian brain and is known to be tightly regulated by various physiological, pathological and pharmacological stimuli. Emerging evidence suggests that various epigenetic mechanisms play important roles in fine‐tuning and coordinating gene expression during adult neurogenesis. Here we review recent progress in our understanding of various epigenetic mechanisms, including DNA methylation, histone modifications and non‐coding RNAs, as well as cross‐talk among these mechanisms, in regulating different aspects of adult mammalian neurogenesis.