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Adult neurogenesis and the plasticity of the dentate gyrus network
Author(s) -
Mongiat Lucas A.,
Schinder Alejandro F.
Publication year - 2011
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2011.07603.x
Subject(s) - dentate gyrus , neurogenesis , neuroscience , granule cell , neuroplasticity , biology , synaptic plasticity , granule (geology) , central nervous system , receptor , paleontology , biochemistry
The granule cell layer (GCL) of the dentate gyrus contains neurons generated during embryonic, early postnatal and adult life. During adulthood there is a continuous production of neuronal cohorts that develop and functionally integrate in the preexisting circuits. This morphogenic process generates a stratified GCL, with the outermost layers containing dentate granule cells (DGCs) generated during perinatal life, and the innermost layers containing adult‐born DGCs. In this review we analyse the functional profile of the different neuronal populations of the GCL, with an emphasis on adult‐born neurons as they develop, mature and integrate in the dentate gyrus network. We focus on the contribution of adult‐born neurons to activity‐dependent synaptic modification in the dentate gyrus and, in turn, discuss how network activity modulates integration and survival of new neurons.