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Perspectives on adult neurogenesis
Author(s) -
Knobloch Marlen,
Jessberger Sebastian
Publication year - 2011
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2010.07598.x
Subject(s) - neurogenesis , subventricular zone , neuroscience , subgranular zone , glutamatergic , olfactory bulb , dentate gyrus , biology , rostral migratory stream , neural stem cell , hippocampal formation , stem cell , glutamate receptor , microbiology and biotechnology , central nervous system , biochemistry , receptor
New neurons are generated throughout life. This discovery has challenged firmly held concepts about the structural plasticity and regenerative capacity of the mammalian brain. In this special issue of the EJN, leaders in the field summarize and review recent advances aiming to understand the molecular mechanisms underlying adult neurogenesis and the impact of new neurons on brain function in health and disease. Below we discuss pivotal yet unsolved aspects of adult neurogenesis as well as potential future directions in the field.