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Neurogranin phosphorylation fine‐tunes long‐term potentiation
Author(s) -
Zhong Ling,
Kaleka Kanwardeep S.,
Gerges Nashaat Z.
Publication year - 2011
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2010.07506.x
Subject(s) - long term potentiation , neurogranin , postsynaptic potential , neuroscience , excitatory postsynaptic potential , neurotransmission , hippocampal formation , phosphorylation , chemistry , glutamate receptor , long term depression , biology , microbiology and biotechnology , ampa receptor , receptor , protein kinase c , biochemistry , inhibitory postsynaptic potential
Learning‐related potentiation of synaptic strength at Cornu ammonis subfield 1 (CA1) hippocampal excitatory synapses is dependent on neuronal activity and the activation of glutamate receptors. However, molecular mechanisms that regulate and fine‐tune the expression of long‐term potentiation (LTP) are not well understood. Recently it has been indicated that neurogranin (Ng), a neuron‐specific, postsynaptic protein that is phosphorylated by protein kinase C, potentiates synaptic transmission in an LTP‐like manner. Here, we report that a Ng mutant that is unable to be phosphorylated cannot potentiate synaptic transmission in rat CA1 hippocampal neurons and results in a submaximal expression of LTP. Our results provide the first evidence that the phosphorylation of Ng can regulate LTP expression.