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Autophagy, inflammation and neurodegenerative disease
Author(s) -
Alirezaei Mehrdad,
Kemball Christopher C.,
Whitton J. Lindsay
Publication year - 2011
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2010.07500.x
Subject(s) - autophagy , neuroscience , regulator , disease , inflammation , central nervous system , homeostasis , biology , neurodegeneration , medicine , microbiology and biotechnology , immunology , pathology , apoptosis , biochemistry , gene
Autophagy is emerging as a central regulator of cellular health and disease and, in the central nervous system (CNS), this homeostatic process appears to influence synaptic growth and plasticity. Herein, we review the evidence that dysregulation of autophagy may contribute to several neurodegenerative diseases of the CNS. Up‐regulation of autophagy may prevent, delay or ameliorate at least some of these disorders, and – based on recent findings from our laboratory – we speculate that this goal may be achieved using a safe, simple and inexpensive approach.