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Deep brain stimulation in clinical trials and animal models of depression
Author(s) -
Hamani Clement,
Nóbrega José N.
Publication year - 2010
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2010.07414.x
Subject(s) - deep brain stimulation , depression (economics) , antidepressant , animal models of depression , neuroscience , clinical trial , stimulation , brain stimulation , medicine , psychology , translation (biology) , biology , parkinson's disease , disease , hippocampus , economics , macroeconomics , biochemistry , messenger rna , gene
Deep brain stimulation (DBS) is currently being investigated as a therapy for the treatment of depression. Despite promising results of recent clinical trials, neural and chemical mechanisms responsible for the effects of stimulation are still unclear. In this article, we review clinical and laboratory findings on DBS for depression. Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats.