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Mitochondrial trafficking and the provision of energy and calcium buffering at excitatory synapses
Author(s) -
MacAskill Andrew F.,
Atkin Talia A.,
Kittler Josef T.
Publication year - 2010
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2010.07345.x
Subject(s) - excitatory postsynaptic potential , neuroscience , synaptic plasticity , postsynaptic potential , mitochondrion , biology , synapse , nervous system , inhibitory postsynaptic potential , microbiology and biotechnology , receptor , biochemistry
Neuronal postsynaptic currents consume most of the brain’s energy supply. Delineating how neurons control the distribution, morphology and function of the energy‐producing mitochondria that fuel synaptic communication is therefore important for our understanding of nervous system function and pathology. Here we review recent insights into the molecular mechanisms that control activity‐dependent regulation of mitochondrial trafficking, morphology and activity at excitatory synapses. We also consider some implications of this regulation for synaptic function and plasticity and discuss how this may contribute to synaptic dysfunction and signalling in neurological disease, with a focus on Alzheimer’s disease.