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NR2B subunit‐dependent long‐term potentiation enhancement in the rat cortical auditory system in vivo following masking of patterned auditory input by white noise exposure during early postnatal life
Author(s) -
Hogsden Jennifer L.,
Dringenberg Hans C.
Publication year - 2009
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2009.06835.x
Subject(s) - long term potentiation , nmda receptor , auditory cortex , neuroscience , synaptic plasticity , postsynaptic potential , biology , chemistry , medicine , receptor
The composition of N ‐methyl‐ d ‐aspartate (NMDA) receptor subunits influences the degree of synaptic plasticity expressed during development and into adulthood. Here, we show that theta‐burst stimulation of the medial geniculate nucleus reliably induced NMDA receptor‐dependent long‐term potentiation (LTP) of field postsynaptic potentials recorded in the primary auditory cortex (A1) of urethane‐anesthetized rats. Furthermore, substantially greater levels of LTP were elicited in juvenile animals (30–37 days old; ∼55% maximal potentiation) than in adult animals (∼30% potentiation). Masking patterned sound via continuous white noise exposure during early postnatal life (from postnatal day 5 to postnatal day 50–60) resulted in enhanced, juvenile‐like levels of LTP (∼70% maximal potentiation) relative to age‐matched controls reared in unaltered acoustic environments (∼30%). Rats reared in white noise and then placed in unaltered acoustic environments for 40–50 days showed levels of LTP comparable to those of adult controls, indicating that white noise rearing results in a form of developmental arrest that can be overcome by subsequent patterned sound exposure. We explored the mechanisms mediating white noise‐induced plasticity enhancements by local NR2B subunit antagonist application in A1. NR2B subunit antagonists (Ro 25‐6981 or ifenprodil) completely reversed white noise‐induced LTP enhancement at concentrations that did not affect LTP in adult or age‐matched controls. We conclude that white noise exposure during early postnatal life results in the maintenance of juvenile‐like, higher levels of plasticity in A1, an effect that appears to be critically dependent on NR2B subunit activation.