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Specific role of the posterior dorsal hippocampus–prefrontal cortex in short‐term working memory
Author(s) -
Izaki Yoshinori,
Takita Masatoshi,
Akema Tatsuo
Publication year - 2008
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2008.06284.x
Subject(s) - working memory , prefrontal cortex , neuroscience , lesion , hippocampus , psychology , dorsum , ibotenic acid , medicine , anatomy , central nervous system , cognition , psychiatry
Working memory in rats involves neural projections from the hippocampus (HP) to the prefrontal cortex (PFC), based on delayed task experiments in a radial‐arm maze, in which the time span of working memory is longer than seconds. To determine whether the HP–PFC pathway is involved in short‐term (on the order of seconds) working memory function, we lesioned the PFC and/or HP, and measured performance in an operant delayed alternation task. The posterior dorsal (pdHP) and ventral HP (vHP) were assessed separately. The bilateral PFC and bilateral pdHP ibotenate lesions produced significant working memory deficits, but the vHP lesion did not. Unilateral pdHP lesions combined with a PFC lesion in the opposite hemisphere reproduced the effects of bilaterally symmetrical lesions. By contrast, unilateral lesions of the pdHP combined with a PFC lesion in the same hemisphere had no effect on delayed alternation. These results indicate that the pdHP–PFC pathway is essential for working memory on the order of seconds in rats, and suggest that the pdHP and vHP pathways to the PFC play different behavioral roles.