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Towards unravelling task‐related modulations of neuroplastic changes induced in the human motor cortex
Author(s) -
Antal Andrea,
Terney Daniella,
Poreisz Csaba,
Paulus Walter
Publication year - 2007
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2007.05896.x
Subject(s) - transcranial direct current stimulation , stimulation , neuroscience , motor cortex , neuroplasticity , psychology , primary motor cortex , brain stimulation , transcranial magnetic stimulation , cognition
Stimulation with weak electrical direct currents has been shown to be capable of inducing stimulation‐polarity‐dependent prolonged diminutions or elevations of cortical excitability, most probably elicited by a hyper‐ or depolarization of resting membrane potentials. The aim of the present study was to test if cognitive task and motor exercise practiced during the stimulation are able to modify transcranial direct current stimulation‐induced plasticity in the left primary motor cortex in 12 healthy subjects. Motor evoked potentials were recorded before and after 10 min of anodal and cathodal transcranial direct current stimulation. In Experiment 1, subjects were required to sit passively during the stimulation, in Experiment 2 the subject's attention was directed towards a cognitive test and in Experiment 3 subjects were instructed to push a ball in their right hand. Both the cognitive task and motor exercise modified transcranial direct current stimulation‐induced plasticity; when performing the cognitive task during stimulation the motor cortex excitability was lower after anodal stimulation and higher after cathodal stimulation, compared with the passive condition. When performing the motor exercise, the motor cortex excitability was lower after both anodal and cathodal stimulation, compared with the passive condition. Our results show that transcranial direct current stimulation‐induced plasticity is highly dependent on the state of the subject during stimulation.