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Substance P excites globus pallidus neurons in vivo
Author(s) -
Cui QiaoLing,
Yung WingHo,
Xue Yan,
Chen Lei
Publication year - 2007
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2007.05803.x
Subject(s) - globus pallidus , substance p , medicine , agonist , tachykinin receptor , tachykinin receptor 1 , endocrinology , excitatory postsynaptic potential , neuroscience , receptor , basal ganglia , neuropeptide , biology , central nervous system
Substance P is a member of the neurokinin family. Previous studies have reported the existence of substance P and its high‐affinity receptor, neurokinin‐1 receptor, in globus pallidus. Employing in vivo extracellular recording combined with behavioural tests, the effects of substance P in globus pallidus of rats were studied. Micropressure ejection of the selective neurokinin‐1 receptor agonist [Sar9,Met(O2)11] substance P increased the spontaneous firing rate of pallidal neurons in a concentration‐dependent manner, with increases of 27.3% at 0.01, 33.4% at 0.03, 45.5% at 0.1, 38.4% at 0.3 and 36.4% at 1.0 m m . The selective neurokinin‐1 receptor antagonist SR140333B prevented the excitatory effects induced by [Sar9,Met(O2)11] substance P. In behaving rats, we observed the postural effects of neurokinin‐1 receptor activation in the globus pallidus. Consistent with electrophysiological results, unilateral microinjection of [Sar9,Met(O2)11] substance P (0.1 m m ) led to a SR140333B‐sensitive contralateral deflection in the presence of systemic haloperidol administration. Combining electrophysiological and behavioural findings, we concluded that substance P produces excitatory effects on globus pallidus neurons via neurokinin‐1 receptors.