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CD4 + CD25 – effector T‐cells inhibit hippocampal long‐term potentiation in vitro
Author(s) -
Lewitus Gil M.,
Zhu Julia,
Xiong Huangui,
Hallworth Richard,
Kipnis Jonathan
Publication year - 2007
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2007.05788.x
Subject(s) - long term potentiation , neuroinflammation , hippocampal formation , neuroscience , hippocampus , stimulation , blockade , il 2 receptor , multiple sclerosis , biology , microbiology and biotechnology , receptor , chemistry , immunology , t cell , immune system , inflammation , biochemistry
During neuroinflammation T‐cells invade the CNS, and may lead to the development and progression of several pathologies, of which multiple sclerosis is the most common. In these pathologies neuroinflammation is often associated with cognitive dysfunction. Using mouse hippocampal slices, we show here that CD4 + CD25 – T‐cells inhibit long‐term potentiation (LTP) induced by high‐frequency stimulation. The T‐cell‐mediated inhibition of LTP can be prevented by blockade of γ‐aminobutyric acid (GABA) A receptors. These findings provide additional insight into the multiple functions of T‐cells in CNS pathologies.