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dextro ‐Naloxone or levo ‐naloxone reverses the attenuation of morphine antinociception induced by lipopolysaccharide in the mouse spinal cord via a non‐opioid mechanism
Author(s) -
Wu HsiangEn,
Sun HanSen,
Cheng Caleb W.,
Terashvili Maia,
Tseng Leon F.
Publication year - 2006
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2006.05144.x
Subject(s) - (+) naloxone , morphine , opioid , pharmacology , spinal cord , chemistry , medicine , endocrinology , receptor , psychiatry
Glial stimulation by intrathecal injection of lipopolysaccharide (LPS) attenuated the tail‐flick inhibition produced by morphine given intrathecally in the spinal cord of the male CD‐1 mice. The phenomenon has been defined as antianalgesia. The effects of dextro ‐naloxone or levo ‐naloxone on the attenuation of morphine‐produced tail‐flick inhibition induced by LPS were then studied. Pretreatment with dextro ‐naloxone or levo ‐naloxone reversed the attenuation of the morphine‐produced tail‐flick inhibition induced by LPS. Pretreatment with dextro ‐naloxone or levo ‐naloxone alone did not affect the morphine‐produced tail‐flick inhibition. It is concluded that dextro ‐naloxone and levo ‐naloxone block the LPS‐induced antianalgesia against morphine antinociception via a non‐opioid mechanism.