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ErbB receptor signalling regulates dendrite formation in mouse cerebellar granule cells in vivo
Author(s) -
Rieff Heather I.,
Corfas Gabriel
Publication year - 2006
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2006.04727.x
Subject(s) - erbb , neuregulin , microbiology and biotechnology , postsynaptic potential , neurotransmitter receptor , cerebellum , neuroscience , dendrite (mathematics) , biology , crosstalk , granule (geology) , neuregulin 1 , receptor , signal transduction , paleontology , biochemistry , physics , geometry , mathematics , optics
The formation of morphologically and functionally mature dendrites is a key event in neuronal maturation and the establishment of functional neuronal networks, but the signals that regulate mammalian dendritic development remain poorly understood. Here we show that the erbB receptor signalling pathway, which modulates expression of several neurotransmitter receptors, also regulates dendritic development of cerebellar granule cells in the intact cerebellum. These results suggest that neuregulin–erbB signalling may control a program of postsynaptic development, from initiating dendrite morphogenesis to the formation and maturation of the postsynaptic apparatus.