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Cortical reorganization after brain damage: the oculomotor model
Author(s) -
Nyffeler Thomas,
Müri René,
Pflugshaupt Tobias,
Wartburg Roman,
Hess Christian W.
Publication year - 2006
Publication title -
european journal of neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.346
H-Index - 206
eISSN - 1460-9568
pISSN - 0953-816X
DOI - 10.1111/j.1460-9568.2006.04648.x
Subject(s) - saccade , eye movement , neuroscience , lesion , transcranial magnetic stimulation , psychology , supplementary eye field , oculomotor nucleus , stimulation , midbrain , central nervous system , psychiatry
Recovery from eye movement deficits after cortical lesions is amazingly rapid and almost complete, which is in sharp contrast to most other neurological deficits of cerebral lesions. The underlying mechanisms of this successful recovery remain uncertain. We had the rare opportunity to examine two patients with recovery from saccade deficits after a lesion restricted to the frontal eye field (FEF) by means of transcranial magnetic stimulation (TMS). The results provide direct evidence that recovery depended on the integrity of the oculomotor regions of the nonlesioned contralesional hemisphere, and that the compensatory network is task‐specific.